The pioneer of anticancer drugs: cisplatin

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August undefined, 2024

Webb1 juli 2024 · Abstract. Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its ... WebbDespite the fact that CRS/HIPEC practices are widely variable, 12,42 the majority of HIPEC studies on ovarian cancer have used i.p. cisplatin, 8,12,42,43 which could also be employed in routine clinical practice as a single agent according to most experts. 42 The duration of perfusion with this drug may reach 160 minutes (usually ranging from 30 to 120 …

Anticancer metallodrugs: where is the next cisplatin? - PubMed

The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division … WebbIn this work, two thiourea ligands bearing a phosphine group in one arm and in the other a phenyl group (T2) or 3,5-di-CF3 substituted phenyl ring (T1) have been prepared and their coordination to Au and Ag has been studied. A different behavior is observed for gold complexes, a linear geometry with coordination only to the phosphorus atom or an … cucs planted in containers

Computational metallomics of the anticancer drug cisplatin

WebbAbstract. Cisplatin is one of the most widely used chemotherapeutic agents for various … WebbAbstract. Platinum (Pt) compounds entered the clinic as anticancer agents when … WebbEncapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its … cucs tapachula moodle

Encapsulation of cisplatin in long-circulating and pH-sensitive ...

Cellular processing of platinum anticancer drugs - Nature

WebbKey Points. Cisplatin, a chemotherapy drug, is best known for curing testicular cancer.; Prior to the discovery of cisplatin, men with testicular cancer had few medical options. Cisplatin is also used in the treatment … WebbProject design, analysis, and regulation of in vitro and in vivo research for cancer targeting, mechanism of action, bio distribution, dosing regimens, and tumor efficacy prepared for FDA... easter chocolate marshmallow eggsWebbThe story of the invention of the anticancer drug cisplatin is a story of chemistry hidden … easter chocolate nests cornflakes

"WebbAmong the platinum-based anticancer drugs, Cisplatin (cis-diamine dichloroplatinum (II), cis- [Pt (NH3)2Cl2]) is one of the most potent components of cancer chemotherapy. The nephrotoxicity, neurotoxicity and ototoxicity, and platinum compounds associated resistant cancer are some major disadvantages. " - The pioneer of anticancer drugs: cisplatin

The pioneer of anticancer drugs: cisplatin

Advanced nanomaterials targeting hypoxia to enhance radiotherapy

WebbWe summarized the recent 5 years of different research progress on clinical applications and antitumor mechanisms of TCM in the treatment of lung cancer. As a ... [EGFRs] tyrosine kinase inhibitors [TKIs]) effects as well as provide synergistic effects, enhance chemotherapy drugs chemosensitivity, reverse drug resistance, reduce adverse ... http://www.dxhx.pku.edu.cn/EN/Y2024/V35/I1/40

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WebbCisplatin has been clinically used as an anticancer drug and a radiosensitizer. Cisplatin can induce cell-cycle arrest, inhibit DNA replication, and trigger apoptosis as well as Auger electron generation owing to the high Z number of platinum. Nonetheless, the use of free cisplatin in chemoradiotherapy is limited owing to its toxicity ... Webb10 mars 2015 · The history of cisplatin starts not in 1965, but in 1844, when it was first …

Webb19 juli 2024 · The Pt(II) complex cisplatin is used as an anticancer drug. Cisplatin … WebbCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is …

Webb1 juli 2024 · Cisplatin is considered as first generation platinum based anticancer drug as it’s anticancer property was discovered first. The second and third generation platinum drugs are similar to the cisplatin but leaving groups or ammine groups are different. This article highlights a systematic description on cisplatin which includes a … WebbThe rediscovery of platinum-based cancer therapy Platinum (Pt) compounds entered the …

Webb24 mars 2005 · Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are …

WebbThe initial pioneering efforts of Clearfield and Alberti are being continued by numerous research groups providing new exciting areas of development on the chemistry of layered M ... We report the use of zirconium phosphate (ZrP) nanoplatelets for the encapsulation of the anticancer drug cisplatin and its delivery to tumor cells. cucs tonalaWebb12 nov. 2024 · This is a crucial step in the early stages of the drug development pipeline and raises the chances of a drug candidate making it through the clinical assessment phases. For instance, the mode of action of anticancer complexes such as cisplatin and related analogues has been established through thorough mechanistic investigations … easter chocolate nestWebbAbstract: This review provides a brief view of the cisplatin's mechanism of action, toxicity … easter chocolate nests with cerealWebb15 juni 2010 · Uptake of the anticancer drug cisplatin is mediated by the copper transporter CTR1 in cultured cells. Here we show in human ovarian tumors that low levels of Ctr1 mRNA are associated with poor clinical response to platinum-based therapy. Using a mouse model of human cervical cancer, we demonstrate t … easter chocolate online australiaWebb7 feb. 2024 · Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such as lack of selectivity, high systemic toxicity, and drug resistance, seriously limit their clinical application. With advancements in nanotechnology and chemical synthesis, Pt ... easter chocolate on saleWebb17 jan. 2024 · A simple, sensitive and repeatable D 2 O-single cell Raman spectroscopy method is developed to quantify the inhibitory activity of anticancer drugs on cancer cell metabolism. The IC 50 values obtained from A549 cells incubated with cisplatin and taxol are comparable with results of CCK-8 and ATP luminescent cell viability assays. easter chocolate nests recipe shredded wheatWebbSummary. Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Since … cuc stunt school