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WebOct 13, 2024 · The accumulation of TDP-43 aggregates in the central nervous system is a common feature of many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia ... WebDec 8, 2024 · A double-spiral-fold structure lies at the centre of TDP-43 filaments. In some neurodegenerative diseases, a protein called TDP-43 forms aggregates in the brain, resulting in neuronal cell death ... WebAug 16, 2024 · A buildup of the protein transactive response DNA-binding protein 43 (TDP-43) may be another sign of LATE. This naturally occurring protein helps with nerve development. This buildup of TDP-43 is usually found in the part of the brain that supports memory, emotion, behavior and mood (limbic system). diatomaceous earth food grade ebay