Glycophorin a dimer
WebNov 1, 2010 · We chose to test the method on a high affinity transmembrane helix dimer, glycophorin A (GpATM). GpATM is a single transmembrane helix that forms a strong homodimer in detergent micelles and lipid bilayers (10–12).It has served as an important model system to study the lateral transmembrane helix–helix interactions that occur in … WebJul 29, 2015 · Therefore, we present structural information on the glycophorin A dimer distribution in the plasma membrane in the absence of other factors like e.g. lipid anchors in a coarse grain resolution.
Glycophorin a dimer
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WebApr 10, 2024 · Transmembrane signaling by receptor tyrosine kinases typically involves a dynamic receptor monomer-dimer equilibrium in which ligand binding to soluble extracellular domains triggers receptor dimer... WebOct 7, 2016 · Lemmon MA, Flanagan JM, Hunt JF, Adair BD, Bormann BJ, Dempsey CE, Engelman DM. Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. J Biol Chem. 1992 Apr 15; 267 (11):7683–7689. [Google Scholar] Lemmon MA, Flanagan JM, Treutlein HR, Zhang J, Engelman DM.
Webglycophorin A (GpA)’ forms SDS-stable dimers through in- teractions mediated by its single transmembrane domain, which contains no strongly polar residues (Furthmayr … WebThe hydrophobic transmembrane domain of glycophorin A contains a sequence motif that mediates dimerization in membrane environments. Long-range interhelical distance measurements using magic angle spinning NMR spectroscopy provide high-resolution structural constraints on the packing of the dimer interface in membrane bilayers. We …
WebThe human erythrocyte sialoglycoprotein, Glycophorin A (GpA), forms dimers that are stable under the conditions of SDS PAGE, and the interactions of its single transmembrane domain drive the association. ... and that the structure of the GpA dimer is a right-handed supercoil with a closely packed dimer interface. Keywords. Epidermal Growth ...
WebMar 15, 1998 · Glycophorin A is the major transmembrane sialoglycoprotein of red blood cells. It has been shown to contribute to the expression of the MN and Wright blood group antigens, ... The GPA panel shows the position of the dimer. No monomeric GPA was detected (data reviewed, but not shown). It should be noted that each membrane fraction …
WebMay 5, 2024 · In the erythrocyte membrane, the interactions between glycophorin A (GPA) and Band 3 are associated strongly with the biological function of the membrane and several blood disorders. In this work, using coarse-grained molecular-dynamics simulations, we systematically investigate the effects of cholesterol and phosphatidylinositol-4,5 … thunder road live at the capital theatreWebAug 20, 2004 · In the presence of an intact GxxxG motif, the glycophorin A dimer stability can be modulated over a span of -0.5 kcal mol (-1) to +3.2 kcal mol (-1) by mutating the surrounding sequence context. Thus, these flanking residues play an active role in determining the transmembrane dimer stability. To assess the structural consequences … thunder road midi fileWebMay 1, 2002 · The transmembrane domain of glycophorin A is largely composed of hydrophobic amino acids and has a seven-residue motif that mediates dimerization in membrane bilayers ().There has been considerable interest in establishing the detailed structure of the helix-to-helix contacts in the dimer interface to address the general … thunder road live 1975WebMar 1, 2004 · Here we carry out a series of experiments on the glycophorin A transmembrane dimer in micellar C14 betaine. The glycophorin A transmembrane helix … thunder road lyrics deutschWebGlycophorin was already introduced as a glycoprotein. Carbohydrates may be bonded to the protein through the alcohol of serine or threonine. ... (2007) applied simple algorithm … thunder road lyrics debateWebOct 28, 2015 · Crystal Structure of the Glycophorin A Transmembrane Monomer in Lipidic Cubic Phase. ... Crystal Structure of the Glycophorin A Transmembrane Dimer in Lipidic Cubic Phase. Trenker, R., Call, M.E., Call, M.J. (2015) J Am Chem Soc 137: 15676-15679. PubMed: 26642914 Search on PubMed; thunder road lyrics and chordsWebJul 29, 2015 · The protein dimer was exclusively sorted into the domain of L d character in the model red blood cell plasma membrane. Therefore, we present structural information … thunder road motorcycle transport