WebBrandon Chen 1 , Nupur K Das 1 , Indrani Talukder 1 , Rashi Singhal 1 , Cristina Castillo 1 , Anthony Andren 1 , Joseph D Mancias 2 , Costas A Lyssiotis 3 , Yatrik M Shah 4 Affiliations 1 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA. WebApr 13, 2024 · How cell metabolism regulates DNA repair is incompletely understood. Here, we define a GTP-mediated signaling cascade that links metabolism to DNA repair and has significant therapeutic implications. GTP, but not other nucleotides, regulates the activity of Rac1, a G protein, that promotes the dephosphorylation of serine 323 on Abl-interactor 1 …
Lab Members Lyssiotis Laboratory - University of Michigan
WebJan 27, 2024 · We need to think about this challenge differently," said Costas Lyssiotis, Ph.D., the lead investigator on the study. ... Lyssiotis and his lab wanted to understand hyaluronic acid beyond its ... WebLyssiotis CA, et al. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nature Cancer. 3: 1386-1403. PMID 36411320 DOI: 10.1038/s43018-022-00463-1 : 0.836: 2024: Kumar A, Yarosz EL, Andren A, Zhang L, Lyssiotis CA, Chang CH. NKT cells adopt a glutamine ... huluwaservice gmail.com
Pancreatic cancer cells shown to feed on hyaluronic acid
WebMar 15, 2024 · UNLABELLED: To identify novel drivers of malignancy in pancreatic ductal adenocarcinoma (PDAC), we employed regulatory network analysis, which calculates the activity of transcription factors and other regulatory proteins based on the integrated expression of their positive and negative target genes. We generated a regulatory … WebCostas Lyssiotis. Orcid identifier 0000-0001-9309-6141. Associate Professor. MM Molecular and Integrative Physiology. Director, Academic Program. MM Cancer Biology Graduate Program. Associate Professor. MM Internal Medicine - … WebSam obtained his bachelor's degree in biochemistry from Calvin College in 2014. He worked as a research technician before joining the doctoral program in Cancer Biology in 2024. Now, he conducts research in the laboratory of Dr. Costas Lyssiotis studying how metabolism is deregulated in pancreatic cancer. Sam's hobbies include running, brewing ... huluwa hair-drying towel